血浆脂蛋白（a）、载脂蛋白A＿1、B与非胰岛素依赖型糖尿病大血管病变的关系

Relatlonship of Plasma Lipoprotein(a),Apolipoprotein A1 and B Levels to Macroanglopathy in Patients with NIDDM

测定了５８例非胰岛素依赖型糖尿病（ＮＩＤＤＭ）病人及４８例正常人的血浆Ｌｐ（ａ）、ＡｐｏＡ１和ＡｐｏＢ浓度。ＮＩＤＤＭ并发大血管病变组与无血管病变组比较，Ｌｐ（ａ）浓度升高，差异极显著，ＡｐｏＢ升高显著（Ｐ＜０．０５），ＡｐｏＡ１降低显著（Ｐ＜０．０１）。血浆Ｌｐ（ａ）与ＡｐｏＡ１、ＡｐｏＢ无显著相关性。提示Ｌｐ（ａ）、ＡｐｏＡ１、ＡｐｏＢ异常都是ＮＩＤＤＭ大血管病变的危险因素之一。

he levels of plasma lipoprotein(a) Lp(a) ,apolipoprotein A1(ApoA1), apolipoprotein B(ApoB),were measured in 48 healthy subjects and 58 NIDDM patients including 29 cases with macroangiopathyand 29 without it.The levels of plasma Lp(a),ApoB in NIDDM patients with macroangiopathy wereall signiricantly higher than those in the patients without it,the level of ApoA1 was significantly lower,but the level of Lp(a) was even higher. There was no remarkable correlation between the level of plas-ma Lp(a)and the levels of plasma ApoA1,ApoB in NIDDM patients. The results suggested that thehigh Lp(a)level was of closer relationship to the incidence of NIDDM macroangiopathy than the levelsof ApoA1,ApoB. Lp(a)is an independent risk factor for NIDDM madcroangiopathy.