兔颅骨冠状缝固定后行额骨前徙与颅面补偿性生长变化的实验研究

Experimental Study of Frontal Bone Advancement and Compensatory Craniofacial Growth Changes After Coronal Suture Immobilization in Rabbits

用２周龄幼兔做实验对象，分成３个实验组。用ＥＢ复合树脂在两侧冠状缝表面形成长１０ｍｍ宽３ｍｍ固定带，模拟人类冠状缝早闭。第６周解除固定带，同时行单纯额骨切开术和额骨前徙术。术后不同时期分别测量颅面长度，鼻骨长度，面角和腭角。结果发现，冠状缝固定后，颅面生长朝颅底方面改向。单纯颅骨切开组面平面发生明显改变，提示切开部位又重新骨化。而额骨前徙术组面平面无明显改变，但鼻骨增长，颅底面中部关系基本正常。提示额骨前上移术是治疗冠状缝早闭的有效手术方法，与临床相一致。

his study was designed to investigate the changes of frontal bone advancement and compensatorycraniofacial growth in rabbits after coronal suture immobilization. Twenty animals underwent bilateralcoronal suture immobilization, ten animals served as controls. The coronal suture was releassed at 6week of age by frontal bone craniotomy(group 2)or frontal bone advancement(group 3).Postoperativelateral head radiographs were taken at 8,14,and 20 week.Craniofacial length,nasal bone length,fa-cial angle,and palatal angle were measured.The result revealed that craniotomy alone or in combina-tion with frontal bone advancement after immobilization produced different compensatory craniofacialgrowth changes. Animals that underwent craniotomy alone showed restenosis postoperatively which re-sulted in significant changes of the facial plane. Animals that underwent frontal bone advancementshowed overall normal relationship of the cranial base and middle face. These were no significantchanges on facial plane. This experimental findings suggest that frontal bone advancement is a bettersurgical procedure for patients with coronl suture synostosis. The results help us understand basic com-pensatory craniofacial growth mechanism in surgical management of patients with craniofacial anoma-lies.