摘要
用正交设计实验和差示扫描量热法（ＤＳＣ）筛选出制备包结物的最佳制备条件，制备了β－ＣＤ－香豆素、聚乙烯醇－香豆素、β－ＣＤ－聚乙烯醇－香豆素、β－ＣＤ－冰片等６个包结物，并考察了它们热稳定性。包结物在８０℃加热５天，β－ＣＤ－香豆素和聚乙烯醇－香豆素释放率为１００％，而β－ＣＤ－聚乙烯醇－香豆素释放率仅为３９．５％。
The optimum conditions of preparing inclusion complex were investisated by orthogonal design and differential scanning calorimetry (DSC).Six inclusion complexes including β-cyclodextrin (β-CD)-polyrinyl alcohol (PVA)-coumarin et al were prepored. Their thermal stabilities were also studied. Inclusion complexes were heated at 80℃ for five days. It was found that the release rate of β-CD-coumarin and PVA-coumarin was 100%, but the release rate of β-CD-PVA-coumarin was 39.5%.
出处
《中国药科大学学报》
CAS
CSCD
北大核心
1994年第2期76-79,共4页
Journal of China Pharmaceutical University
关键词
正交设计
聚乙烯醇
包结物
热稳定
Orthogonal design
DSC
β-CD inclusion complex
PVA inclusion complex
Stability
