α－L－天冬氨酰－L－苯丙氨酸甲酯的合成

Synthesis of α─L─Aspartyl─L─phenylalanine Methyl Ester

以Ｎ─甲酰─Ｌ─天冬氨酸酐和Ｌ─苯丙氨酸为原料缩合成Ｎ─甲酰─α─Ｌ─天冬氨酰─Ｌ─苯丙氨酸，然后去保护基成α─Ｌ─天氨酰─Ｌ─苯丙氨酸，并酯化得α─Ｌ─天冬氨酰─Ｌ─苯丙氨酸甲酯（α─ＡＰＭ）。产物晶形好，纯度高。

This paper is conncerned with a method for the prepration of α─aspartyl─L─phenyalanine methyl ester which is composed of condensing N─formyl─L─aspartic anhydride and L─phenyl─L─alanine to from N─formyl─α─L─aspartyl─L─phenylalanine,removing the formyl group to form α─L─aspartyl─L─phenylalanine and esterfying to obtain the desired α─L─aspartyl─L─phenylalanine methyl ester α─APM.