老年高血脂患者Apo C检测的临床意义

Clinical Significance of Serum Apolipoprotein C in Senile Hyperlipidemia Patients

目的 探讨老年高血脂患者血清载脂蛋白CⅡ、CⅢ(ApoCⅡ、CⅢ)的变化及意义。方法 免疫比浊法测定老年不同高血脂组血清ApoCⅡ、ApoCⅢ水平,并分析与其他指标的相关性。结果 老年高血脂患者血清Tch、LDL水平各组间无差异(P >0 0 5 ) ,且与TG浓度无明显相关;TG浓度与HDL水平呈负相关关系(r =0 43 5 ,P <0 0 0 1) ,与ApoCⅡ、ApoCⅢ水平呈正相关关系(r =0 478,0 42 6,P <0 0 0 1) :老年高血脂患者血清ApoCⅡ、ApoCⅢ水平在男女性别间无显著性差异(P >0 0 5 )。结论 血清ApoCⅡ、ApoCⅢ水平与动脉粥样硬化危险因子TG呈正相关。

Objective To investigate serum levels of apolipoprotein CⅡ(Apo CⅡ) and apolipoprotein CⅢ (Apo CⅢ) in senile hyperlipidemia patients and their clinical significance.Methods Hyperlipidemia patients were classified into 4 groups according to their serum levels of triglyceride (TG).Apo CⅡ and Apo CⅢ were detected by immunoturbidimetric assay and analyzed with other indexes.Results The serum levels of cholesterol and LDL had no significant differences between groups and no relations to TG.The serum TG level had negative relation to HDL level(r=-0 435,P<0 001),while it had positive relation to Apo C Ⅱ and Apo CⅢ(r=0 478,0 426,P<0 001).Male and female senile hyperlipemia patients had no significant differences in serum levels of Apo C Ⅱ and Apo CⅢ.Conclusions The serum levels of Apo CⅡ and Apo CⅢ have positive relations with serum TG,a risk factor of atherosclerosis,which explains that Apo CⅡ and Apo CⅢ may play roles in the occurrence of cardiovascular disease in senile patients.