摘要
块菌多糖(polysaccharideofTubersinica,PST)是首次从中国块菌中提取的一种新的蛋白结合多糖,民间用于治疗胃癌。为了开发PST的药用价值,研究了其对小鼠肿瘤及免疫系统的影响,结果表明PST连续10dip25mg/kg,50mg/kg能抑制小鼠S-180肉瘤以及EAC肉瘤的生长,但不抑制体外培养Hela细胞的增殖。PST明显增加小鼠脾脏重量,明显促进碳粒廓清速率,增加SRBC所致的小鼠迟发型足垫肿胀度,增加外周血中白细胞数及T淋巴细胞百分率,促进T淋巴细胞转化,提高小鼠血清中IgG水平。
Polysaccharide of Tuber sinica (PST) is a new protein polysaccharide(MW ca.3×104) extracted from Tuber.sinica K.Tao et Liu,which was used in the treatment of stomach cancer in folk medicine.The present paper reported effects of PST on tumor and immune system of mice. The results showed that PST ip 12.5,25,50 mg/kg inhibited the sarcoma proliferation of S-180 and Ehrlich ascitic carcinoma(the inhibition percentage of 50 mg/kg dose group was 50.2%and 35.7%,respectively),but did not affect of proliferation of Hela cells in uitro,PST ip 12.5, 25,50 mg/kg increased weights of spleen of mice,enhanced the clearance rates of charcoal particles and delayed footpad swellings,PST also increased the number of leukocytes,T lymphocytes percentage and lymphocytes transformation of blood in mice,and promoted the level of immunoglobulin G.This study indicated that the tumorinhibiting activity of PST may be related to immunological function in host.
出处
《中国药科大学学报》
CAS
CSCD
北大核心
1994年第5期289-292,共4页
Journal of China Pharmaceutical University
基金
卫生部青年科学基金
关键词
块菌多糖
抗肿瘤活性
T细胞
抗癌药
免疫系统
Polysaccharide of Tuber sinica
Antitumor
Clearance rates of charcoal particles
T Lymphocytes
Delayed footpad swellings