贝凡洛尔与美托洛尔的降压作用比较

Comparative Antihypertensive Effects of Bevantotol and Metoprolol

贝凡格尔１２指肠给药（ｉｄ）对清醒大鼠血压和清醒自发性高血压大鼠（ＳＨＲ）的降压作用比美托洛尔强、显效快，ｉｖ贝凡洛尔对麻醉大鼠、麻醉狗及急性肾性高血压大鼠的降压作用比美托洛尔强。且贝凡洛尔无论ｉｄ还是ｉｖ其降压持续时间均长于美托洛尔。

Bevantolol is a beta-1 adrenoceptor antagonist.By duodenum injection of bevantolol 100 mg/kg in normal concious rats and concious spontaneously hypertensive rats(SHR),the mean blood pressure (MBP)decreased obviously. The MBP decreased percentage(%)is 20.34%and 26.53%,respectively. The hypotensive effect is more potent than that of metoprolol(13.10% and 21.11%,respectively). These hypotensive effects of bevantolol occured at 15 min after duodenum injection,while metoprolol at 30～35 min. In addition, the antihypertensive effect of bevantolul iv 3.6 mg/kg,6.0mg/kg,and 10.0 mg/kg was proved in acute renal hyportensive rats,and the mean blood pressure decreased by 20.37%, 34.02%and 50.17%, respectively. This antihypertensive effect is stronger than that of metoprolol(6.19%, 12. 52% and 20. 37%, respectively). With iv bevantolol of 10mg/kg in anesthetized rats and 6.0 mg/kg,8.6 mg/ kg in anesthetized dogs,MBP decreased by 56.39%(rats), 14. 10%,30. 03%(dogs), respectively. In same doses,metoprolol only decreased by 18.94%(rats), 10. 06%, 21.00%(dogs), respectively. As to the hypotensive effect of bevantolol, it kept longer than that of metoprolol.