摘要
养正合剂(15,30g/kg,po)能显著抑制小鼠移植肉瘤180(S(180))、肝癌实体型(Hepe)及艾氏腹水癌(EAC)的生长,最高抑瘤率分别为47.5%、44.8%及42.1%。养正合剂(15g/kg,po)与低剂量环磷酰胺合用,表现出明显抑制小鼠S(183)瘤的增效作用。养正合剂(15,30g/kg,po)显著升高S(180)小鼠的血清溶血素抗体的含量,30g/kg,po明显增强DNCB所致S(180)小鼠接触性皮炎。
The effects of Yang zheng He Ji(YZHJ) on the tumor growth and immune function in tumor-bearing mice were examined. The results showed that inhibitory rate of YZHJ against S(180),EAC and Heps tumor reached 47.5%, 44.8% and 42.1%, respectively. Combined with YZHJ(15 g/kg,po), the growth inhibition rate of S(180)-tumor was superior to cyclophosphamine (Cy)alone.done. YZHJ(15g/kg,po)increased the inhibition rate of S(180)-tumor weight superior to Cy alone. YZHJ (15,30 g/kg, po)enhanced markedly the content of serum hemolysin antibody in tumor-bearing mice. In addition,YZHJ(30 g/kg, po)also strengthened remarkably the contact dermatitis induced by dinitrochlorobenzene(DNCB) in tumor-bearing mice.
出处
《中国药科大学学报》
CAS
CSCD
北大核心
1994年第6期353-356,共4页
Journal of China Pharmaceutical University
关键词
养正合剂
抗癌药
抗癌药
药理
Yang Zheng He Ji
EAC
Heps
Hemolysin
DNCB-DTH
Antitumor