摘要
Triazolodiazepine (Tri)体外对Con A和LPS诱导的小鼠脾细胞增殖以及巯基乙醇硫酸盐激活的腹腔巨噬细胞吞噬功能呈浓度依赖性抑制作用。Tri还明显抑制Con A诱导的脾细胞释放集落刺激因子和巨噬细胞释放白细胞介素-1,结果提示,Tri抑制小鼠脾细胞和巨唾细胞功能可能与其广泛而强大的抗炎作用有关。
Effects of triazolodiazepine (Tri) on mouse splenocyte proliferation and macrophage phagocytosis were studied. Tri 0. 1 - 10 μmol·L-1 significantly inhibited concanavalin A (Con A) 5 μg·ml-1 and lipopolysaccharides (LPS) 10 μg·ml-1-induced splenocyte proliferation and phagocytic activity of activated peritoneal macrophages. Tri 10 μmol · L-1 reduced Con A-induced. colony stimulating factor release from mouse splenocytes and LPS-challenged intracellular and extracellular interleukin-1 production from peritoneal macrophages. These results partially explain the wide and strong anti-inflammatory effects of Tri.
出处
《中国药理学报》
CSCD
1994年第1期65-68,共4页
Acta Pharmacologica Sinica
关键词
集落刺激因子
脾脏
巨噬细胞
抑制
triazolocliazepine
interleukin-1
colony-stimulating factors
macrophages
phagocytosis
spleen
