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铀氢锆堆中子源辐照含硼C6胶质瘤细胞的生物学效应研究 被引量：1

Biological effects of boron-absorbed C6 glioma cells irradiated by UHZr reactor neutron source
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摘要 利用蒙卡程序MCNP/4B(Monte Carlo N-particle transportcode/4B)设计了C6细胞辐照实验的铀氢锆堆中子源。建立了细胞培养、孵育、L-BPA(L-boron phenylalanine)给药、细胞内宏观硼浓度测定及辐照实验方法,观察了BNCT(Boron neutron capture therapy)辐照实验对体外C6胶质瘤细胞的放射生物学效应,研究了C6细胞BNCT辐照效应与照射剂量之间的关系。试验结果表明,在同等吸收剂量下,BNCT对C6细胞的杀伤作用远远大于γ射线。 A neutron source of UHZr reactor for C6 glioma cells irradiation is designed by MCNP/4B code. Methods for cell culture, incubation, L-BPA administration, boron concentration measurement and the irradiation experiment are described. Radiobiological effects of C6 glioma cells in vitro, which are induced by BNCT, and the relations between the biological effect and the irradiation dose are studied. The results demonstrate that the cytocidal effect of the BNCT method is much more remarkable than that of gamma radiotherapy at the same absorbed dose.
作者 江新标 赵英 曹锐锋 肖艳 陈伟 屠荆 章翔
机构地区 西北核技术研究所 第四军医大学西京医院神经外科
出处 《核技术》 EI CAS CSCD 北大核心 2005年第6期458-462,共5页 Nuclear Techniques
基金 国家自然科学基金资助项目(10375047)
关键词 铀氢锆堆 硼中子俘获治疗 C6胶质瘤细胞 生物效应 Uranium hydrogen zirconium reactor, Boron neutron capture therapy (BNCT), C6 glioma cell, Biological effect
分类号 TL329.2 [核科学技术—核技术及应用]
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共引文献16

同被引文献9

  • 1赵英,王春义,江新标,朱广宁,陈伟,曹锐峰,章翔.ICP-AES法在测量胶质瘤细胞硼含量中的应用[J].中华神经外科疾病研究杂志,2005,4(6):508-511. 被引量：3
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  • 7SMITH D R, JOEL D D, CODERRE J A, et al. Ion microscopy imaging of boron in animal tissue section for neutron capture [M]//HAWTHORNE M F, SHELLY K, WIERSEMA R J. Frontiers in neutron capture therapy: Vol. 2. New York: Kluwer Academic/Plenum Publishers, 2001: 893- 897.
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  • 9KIGER W S, PATEL H, ZAMENHOF R G. BNCT microdosimetry of a rat glioma model with BPA-F or BSH [M]//HAWTHORNE M F,SHELLY K, WIERSEMA R J. Frontiers in neutron capture therapy: Vol. 2. New York: Kluwer Academic/Plenum Publishers, 2001: 1 133-1 138.

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核技术
2005年 第6期

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