四氢小檗碱对血小板聚集和血栓形成的抑制作用(英文)

Inhibitory effect of tetrahydroberberine on platelet aggregation and thrombosis

SD大鼠每天ip THB 30 mg·kg^(-1)共3 d或5 d后,使ADP诱导的血小板聚集程度降低;同剂量ip 1 d,3 d或5 d后,使AA诱导的血小板聚集程度降低,THB在体外抑制AA,ADP和胶原诱导的兔血小板聚集,IC_(50)分别为0.86,1.31和1.10 mmol·L^(-1) THB能抑制AA诱导的兔血小板生成血栓素B_2 THB 15—30 mg·kg^(-1)iv明显抑制大鼠静脉血栓的形成。

Tetrahydroberberine (THB), an alkaloid extracted from Corydalis ambigua, inhibited the rabbit platelet aggregation triggered by arachidonic acid (AA), ADP, and collagen with IC50 of 0.86, 1.31, and 1.10 mmol·L-1, respectively. THB reduced the thromboxane B2(TXB2) generation in rabbit platelet-rich plasma triggered by AA. THB 30 mg·kg-1 ·d-1 ip for 3 or 5 d restrained the ADP-induced platelet aggregation in rats. THE 30mg·kg-1·d-1ip for 1, 3, or 5 d inhibited the AA-induced platelet aggregation in rats. THE 15 - 30 mg·kg-1 iv showed an inhibition of venous thrombosis in rats. The results show that THB is a potent inhibitor of platelet aggregation in vitro and in vivo and is a promising antithrombotic drug.