4-氨基吡啶诱发小鼠舔体反应与肥大细胞释放组胺

4-Aminopyridine-induced licking response and histamine liberation in mice

4-氨基吡啶(4-AP)1 mg·kg^(-1)颈背部sc能诱发小鼠舔体反应,该反应可被苯海拉明、氯苯那敏或阿司咪唑所抑制。重复注射 4-AP可使舔体反应逐渐减少或不发生,且给药部位皮肤组胺含量明显降低。4-AP也能促进小鼠离体腹腔肥大细胞释放组胺,结果表明,4-AP具有释放组胺作用,它诱发的小鼠舔体反应可能与释放组胺有关。

4-Aminopyridine (4-AP) 1 mg · kg-1 sc at the scruff induced a licking response in mice. H1 receptor blockaders , such as diphenhydramine HC1 (1, 10 mg·kg-1, sc at the scruff or 40 mg ·kg-1, ip), chlor-phenamine maleate (20 mg·kg-1, ip ) , and astemizole (2 mg·kg-1 , ig ) , inhibited the licking response caused by 4-AP. Repeated injections of 4-AP (1 mg·kg-1) reduced the times of lick and the histamine content in the skin of injected site. 4-AP also promoted histamine release from incubated mouse peritoneal mast cells (PMC) in a dose-dependent manner. The results indicate that the licking response may originate from the histamine liberation of mast cells.