双苯氟嗪对大鼠实验性脑水肿的保护作用(英文)

Protective effect of dipfluzine on experimental brain edema in rats

用结扎双侧颈总动脉雌性Wistar大鼠比较双苯氟嗪(Dip)与桂利嗪(Cin)对实验性脑水肿的作用。Dip 25—100mg·kg^(-1)ip可又才抗脑水肿引起的大鼠脑缺血性症状,作用强于Cin,两药预处理加后处理作用也强于单独后处理作用。Dip 50 mg·kg^(-1)能减小缺血脑的梗死范围和CBF降低,但并不改变缺血前CBF,提示Dip可能通过维持缺血区的CBF而治疗缺血性脑水肿。

The effects of dipfluzine (1-diphenylmethyl -4-(3-(4- fluorobenzoyl ) ) -piperazine, Dip), a new calcium antagonist developed in China, on experimental brain edema in Wistar rats with bilateral carotid artery ligation were compared with those of cinnarizine (Cin). Dip 25-100 mg · kg-1 ip protected the rats against the characteristic signs of global cerebral ischemia that correlate well with the development of brain edema. Its effects were more potent than those of Cin; and the effects of both drugs were more potent by both pretreatment and posttreat-ment than those by posttreatment alone. Dip 50 mg · kg-1 ip attenuated the reduction in cerebral blood flow (CBF) and the infarct size after occlusion, but did not alter CBF before ischemia. These findings suggested that Dip may be potentially useful to treat ischemic brain edema in part by preserving CBF in the ischemic zone.