Losartan和卡托普利逆转肾血管性高血压大鼠心肌肥厚及心肌肌球蛋白ATP酶同功酶谱(英文)

Regression of cardiac hypertrophy and myosin isoenzyme patterns by losartan and captopril in renovascular hypertensive rats

Losartan (5mg·kg^(-1)·d^(-1)po)和卡托普利(50 mg·kg^(-1)·d^(-1)po)治疗肾性高血压大鼠8周均能在降压的同时降低左室重量34.8％～41.0％,减少左室总蛋白量28.3％～39.4％,使迁移的心肌凝蛋白ATP酶同功酶谱回复正常。表明两药能有效逆转肾性高血压大鼠心肌肥厚及心肌凝蛋白同功酶谱,通过改变心肌凝蛋白ATP酶活性水平改善心肌收缩功能。

To test the effect of losartan and captopril on cardiac hypertrophy and myosin isoenzyme, two-kidney, one-clip (2K1C) ren-ovascular hypertensive rats (RHR) were used. Eight weeks after the onset of hypertension, losartan 5 mg ·kg-1 ·d-1 and captopril 50 mg ·kg -1·d-1 were administered po to 2 groups of RHR, respectively for 8 wk. The results showed that captopril significantly decreased the cardiac mass (607±169 mg vs 1029±132 mg) and total protein content (120±38 mg vs 198 ± 31 mg), concomitant with significant decrease of arterial blood pressure (BP) (15. 4 ± 5.2 kPa vs 28. 5 ±4. 9 kPa). Losartan also induced a significant decrease in cardiac mass (671 ± 116 mg vs 1029±132 mg) and protein content (142±29 mg vs 198±31 mg), as well as significantly lowered the BP (15. 2 ±2.1 kPa vs 28. 5±4. 9 kPa). It is important to be note that both drugs normalized the shift of myosin isoenzyme in RHR. These results indicated that both drugs, having potent anti-hypertensive effects, can effectively reverse the cardiac hypertrophy and abnormal distribution of myosin isoenzyme patterns.