摘要
鹿茸多肽(Pilose antler peptide,PAP)10和20mg·kg^(-1)ip对各种急慢性炎症具有明显的抑制作用。PAP可使大鼠肾上腺中的抗坏血酸和胆固醇含量降低,并使血清皮质醇含量明显升高;用地塞米松阻断垂体后,上述作用仍然存在。于去肾上腺大鼠PAP仍不失其抗炎作用。可见,PAP的抗炎作用不完全依赖于垂体—肾上腺皮质系统。
Pilose antler peptide (PAP: M W : 7200; amino acid residue: 68) isolated from the antlers of Cervus mppon temminck, 10 and 20 mg · kg-1 ip produced inhibitions towards acute and chronic inflammations in a dose-dependent manner. PAP reduced ascorbic acid and cholesterol contents in adrenal glands and decreased the serum hydrocorti-sone level of rats. The reduction of ascorbic acid and cholesterol contents were unaffected by the pretreatment of dexamethasone. PAP also showed an anti-infiammatory action on the swelling of carrageenan-induced hind paw in adrenalectomized rats. The results suggest that the anti-inflammatory effects of PAP do not depend absolutely on pituitary-adrenal system.
出处
《中国药理学报》
CSCD
1994年第3期282-284,共3页
Acta Pharmacologica Sinica
关键词
鹿茸
多肽
非甾体抗炎剂
antlers
peptides
non- steroidal anti-inflammatory agents
pituitary- adrenal system
