一水盐酸环丙沙星晶体空间群的确定

Determination of the Space Group for Ciprofloxacin Hydrochloride Monohydrate Crystals

为深入研究一水盐酸环丙沙星晶体的晶体结构和晶习,实验制备了一水盐酸环丙沙星晶体.采用DSC和TG技术分别分析了一水盐酸环丙沙星晶体的脱水、熔化、分解温度和晶体的水含量;测定了晶体的X射线粉末衍射数据;采用Cerius2分子软件对衍射数据进行指标化.结果表明,晶体属于单斜晶系,其晶胞参数a、b、c和β分别为12.93×10-10m、19.56×10-10m、7.07×10-10m和91.10°,根据消光规律判断其空间群为P21/c.

Ciprofloxacin hydrochloride monohydrate(CPFX) crystals were obtained experimentally. The deaquation,melting, decomposing apex temperatures and water content of ciprofloxacin hydrochloride monohydrate crystals were measured by DSC and TG techniques respectively. The data of X-ray powder diffraction (XRPD) of these crystals were collected experimentally. The indexing results by the software Cerius2 were obtained. The results show that the crystal of ciprofloxacin hydrochloride monohydrate belongs to monoclinic, and the unit cell parameters a, b, c and β are 12.93×10 -10 m, 19.56×10 -10 m , 7.07×10 -10 m,and 91.10° respectively. Based on the indexing results and the extinction principle, the space group for ciprofloxacin hydrochloride monohydrate crystals produced in crystallization experiment is P2_1/c.