摘要
三七总皂甙(PNS)能抑制心肌总ATP酶活力,但对Na^(+)-K^(+)-ATP酶无明显影响。三七皂甙单体Rb_1及Rg_1对心肌总ATP酶活力均有抑制作用,但Rb_1的抑制效力显著大于Rg_1·Rb_1能抑制豚鼠离体心房肌的自律性和收缩性,Rg_1也能抑制豚鼠离体心房肌的自律性,但对心房肌的收缩性却无明显影响。提示PNS抑制心肌收缩力这一作用的主要有效成份是Rb_1·
Effects of total Panax notogin-seng saponins (PNS) and Panax notoginseng saponin monomers Rb1 and Rg1(Rb1, Rg1) on total ATPase and Na(+) - K(+) - exchanging ATPase of guinea pig heart were studied. It was found that PNS inhibited the total my-ocardial ATPase, but had no significant effect on the myocardial Na( + ) - K(+) - exchanging ATPase. The total ATPase was inhibited by Rg1, and more clearly by Rb1. The auto-maticity and contractility of isolated guinea pig atria were inhibited by Rb1. Rg1 decreased the spontaneous frequency of isolated guinea pig right atrium, but not markedly the contractility of the left atrium. These results demonstrate that Rb1 is the main ingredient in PNS.
出处
《中国药理学报》
CSCD
1994年第4期347-350,共4页
Acta Pharmacologica Sinica
基金
Medical Research Foundation of Department of Public Health of Guangxi,№ 9105.
关键词
人参
皂甙
腺苷三磷酸酶
心肌收缩
ginseng
saponins
Na( + )- K[+]-exchanging ATPase
adenosinetriphos- phatase
myocardial contraction
heart atrium
