吗啡、哌替啶及芬太尼对离体兔气管的影响

Effects of morphine, pethidine and fentanyl on isolated rabbit trachea

用电场刺激的方法研究吗啡(Mor),哌替啶(Pet)及芬太尼(Fen)对离体兔气管的影响,结果表明:Mor 53μmol·L^(-1)使气管收缩明显增强(P<0.01);Fen 1.9 μmol·L^(-1)使其明显减弱(P<0.05);Pet 705 μmol·L^(-1)不仅使其明显减弱(P<0.01),并可使之松弛;纳洛酮(Nal)2.2 μmol·L^(-1)对气管无影响(P>0.05),但能逆转Mor对气管的效应。提示:吗啡受体的兴奋可能是引起气管平滑肌收缩的机制之一。

Effects of morphine, pethidine and fentanyl on tension of isolated rabbit trachea were measured by electric field stimulation. Findings obtained were; 1) Morphine 53 μmol·L-1 increased markedly the trachea contraction (P<0. 01) ; 2) Fentanyl 1. 9 μmol ·L-1 decreased the trachea contraction (P< 0. 05) ( 3) Pethidine 705 μmol·L-1 not only decreased markedly the trachea contraction (P < 0. 01), but also relaxed the trachea; 4) Naloxone 2. 2 μmol·L-1 had no inflence on the trachea directly (P>0. 05), but reversed the effect of morphine on the trachea. The results indicated that the excitation of morphine receptor in trachea may be one of the mechanisms of the contraction of the trachea.