呋喃二氢吡啶Ⅰ对犬急性心肌梗死冠脉侧支循环的作用

Effects of furyl-dihydropyriodine I on coro- nary collateral circulation in myocardial in- farction of dogs

本文用冠脉侧支返流技术研究发现,呋喃二氢吡啶Ⅰ 200μg·kg^(-1)冠脉注射,能增加犬心脏急性心肌缺血区的冠脉侧支流量,降低冠脉外周阻力并使心率下降,冠脉收缩压下降。用TTC染色法测定心梗面积,发现治疗组心梗面积从对照组的28.9±1.3％缩小到15.3±1.2％(P<0.01)。表明呋喃二氢吡啶Ⅰ能改善侧支循环,增加缺血区心肌血流量,降低心肌耗氧量,对心肌起保护作用。

Effects of furyl-dihydropyridine I (FDP-1) on collateral circulation were observed in ischemic myocardium of dogs. FDP-1 (200 μg·kg-1) of intracoronary injection increased collateral flow, reduced systemic artery resistance, and coronary systolic pressure in infarcted region and the area of infarction decreased from 28. 9+1. 3 % to 15. 3 +1.2 % (P<0. 01, n = 6). The results indicated that FDP-1 could improve coronary collateral circulation, increase collateral flow in ischemic region, decrease myocardial oxygen demand, and protect myocardial ischemia.