用蒿甲醚和吡喹酮早期治疗兔的血吸虫感染(英文)

Early treatment of schistosomal infection with artemether and praziquantel in rabbits

兔于感染血吸虫尾蚴后d 7或d 21分别开始ig 1次蒿甲醚(Art)10mg·kg^(-1)和吡喹酮(Pra)40mg·kg^(-1),然后每隔1wk ig 1次相同剂量的Art或Pra连给3—4次,减♀虫率达98％以上,且部分兔无♀虫,上述兔经Art或Pra早期治疗后,其肝脏与正常兔相仿,或仅有轻度变化,一些与急性血吸虫病有关的指标测定亦为阴性。

Artemether (Art, β-methyl ether of artemisinin) first synthesized by Shanghai Institute of Materia Medica, Chinese Academy of Sciences, is effective against not only malaria but also schistosomiasis. When rabbits infected with Schistosoma japonicum cercariae for 7 d were treated ig with Art 10 mg·kg-1, the total worm reduction rates were 74.6-76.7%. If Art (10 mg·kg-1) was given once weekly after the first treatment for 3 - 4 times, the total worm reduction rate was > 98 %, and most of the rabbits were free from worms. When praziquantel (Pra) was given ig 40 mg·kg-1 to rabbits on d 21 after infection, and repeated once every week for 3 wk, most rabbits shewed a total worm reduction rate >98 % with their livers showing normal or mild changes, and their parameters relevant to acute schistosomiasis were negative as compared to the controls. Hence Art and Pra are suggested to be used in field trial for control of acute schistosomiasis or reduction of the intensity of schistosomal infection.