茶碱经微处理机程序输注迅速达到期望兔血浆稳态水平(英文)

Microprocessor-programmed infusion of theophylline rapidly attained expected steady-state level in rabbit plasma

自制二室模型药物程序输液泵。向控制器输入兔茶碱药物动力学参数,期望血浆稳态浓度(C_(pss)),体重及时间。输注速率(K_t)=C_(pss)K_(10)V_cwt{1+[(K_(21)-β)/β]EXP(-K_(21)t)},血药浓度预报式为C_((t))=C_(pss)(1-e^(-αt)),依据显示配药液,自动输注。比色法测定血药浓度。96％的执行百分误小于±30％,其绝对值的中位数为8.3％。虽然T_2~1β=6.08h,但输注后30min(5T_2~1α),血药浓度达期望C_(pss)。

A self-made microprocessor-programmed (two-compartmental model) infusion controller was connected with an infusion pump, which achieved an expected steady-state plasma concentration (Cpss) rapidly (5 TO and maintained the level. Theo-phylline was selected as an example, and its pharmacokinetic parameters of rabbits, expected Cpss, body weight (wt), and infusion time (t) were inputted. The programmed infusion rate (.Kt) was determined by the following equation : (Kt) = Cpss · K10 · Vc · wt (1 + [(K21-β)/P]EXP(-K21t)} and the predicted value was calculated by the formula; C(t) = Cpss X [ 1 - EXP ( - at) ]. The needed concentration and total volume of drug were automatically shown on the screen. The drug was automatically infused after pumping, and the plasma concentration of theophylline was measured by colorimetric method. The re- sults showed that the median absolute value of the performance error (MAVPE) was 8. 3 %. Although T1/2b of theophylline was 6. 08 h, the expected Cpss was attained in only 30 min (5 TO after start of infusion and then well maintained.