离体大鼠肝灌流美托洛尔消除的流量依赖性(英文)

Flow dependence of metoprolol elimination in isolated perfused rat liver

用离体大鼠肝灌流方法,研究了稳态时美托洛尔的代谢模型,灌流量分别为10,20和30ml·min^(-1)时;流入肝脏的浓度分别为7.6,5.0和3.4μg·ml^(-1);流出肝脏的浓度分别为1.2,2.0和2.7μg·ml^(-1);肝窦平均浓度分别为3.4,3.2和3.0μg·ml^(-1)。提示流入和流出浓度呈流量依赖性,与‘平行管’模型相符,而与‘充分搅拌’模型不符。

The effect of blood flow rates on hepatic elimination of metoprolol (Met) was studied in a recirculating isolated perfused rat liver system with a constant infusion of Met into the reservoir. This design ensures that, at a steady state, the elimination rate of Met is a constant. The results showed that at flow rates of 10, 20, and 30 ml·min-1, the concentrations of Met entering the liver (Cin) were 7. 6, 5.0, and 3. 4 μg·ml-1 and the concentrations leaving the liver (Cout,) were 1.2, 2. 0, and 2. 7 μg·ml-1, while the logarithmic average concentrations in hepatocytes (C) were 3.4, 3.2, and 3.0 μg·ml-1, respectively. It is concluded that the hepatic elimination of Met is flow-dependent, which is in accordance with the 'parallel tube' model.