脑动脉上神经纤维存在强啡肽A(英文)

Nerve fibers containing dynorphin A in cerebral arteries

免疫组织化学方法显示豚鼠脑动脉上有含强啡肽A_(1-17)免疫样物质的神经纤维存在,大脑前和中动脉上分布最高。乙醛酸诱发荧光法显示有丰富的单胺能神经纤维分布在大的和小的脑血管上,大鼠预先给予6-羟多巴胺或利血平,血管壁上强啡肽含量明显下降。以上结果提示:血管壁上有强啡肽A纤维存在,并且它可能与单胺类神经递质共存。

Nerve fibers containing dynor-phin (Dyn) A(1-17)-like immunoreactivity were identified around cerebral arteries of guinea pig. The immunoreactive nerve fibers were richly distributed in anterior and middle cerebral arteries, but sparsely in posterior cerebral and basilar arteries. Histofluorescent study showed that large and small cerebral arteries were abundantly innervated by monoamine nerve fibers. Pretreatment with 6-hydroxydopamine or reserpine reduced the concentration of Dyn A in the wall of arteries by about 60 % and 30 %, respectively. These results demonstrated that there exist Dyn A immuoreactive nerve fibers in cerebral arteries and Dyn A may coexist with monoamine in perivascular nerve fibers.