摘要
感染11个月的小鼠细粒棘球蚴囊壁与囊液分别含有18种和23种游离氨基酸。除牛磺酸外,囊液中的游离氨基酸含量均较囊壁的为高。用甲苯达唑25mg·kg^(-1)·d^(-1)×14d与50mg·kg^(-1)·d^(-1)×7d ig治疗小鼠后,囊壁与囊液的丙氨酸、缬氨酸、赖氨酸及牛磺酸的含量均明显增高,以囊壁的丙氨酸的增高为最显著。
Eighteen and 23 FAA components were detected in the cyst wall and cyst fluid of E granulosus, respectively, by using automatic amino acid analyzer. The concentrations of most of the determined FAA were higher in the cyst fluid than those in the cyst wall, especially the taurine was 5-fold higher. Mebendazole treatment resulted in an increase in the concentration of alanine, valine, lysine, and taurine in both cyst wall and cyst fluid, the most notable being the alanine in the cyst wall. The results are interpreted as a coupling of glycolysis and amino acid metabolism, suggesting an involvement of FAA metabolism in the mechanism of Meb action.
出处
《中国药理学报》
CSCD
1994年第6期521-524,共4页
Acta Pharmacologica Sinica
基金
National Natural Science Foundation of China,№ 39070759.