摘要
观察盐酸川芎嗪（ＴＭＰＨ）３０ｍｇ·ｋｇ－１ｉｖ后大白鼠心、肝、脾、肾、脑、肌肉、睾丸和血浆等组织中药物浓度的经时变化。统计矩分析结果表明：肝脏摄取率最高，ＡＵＣ为２４７．９ｍｇ·ｈ－１·Ｌ－１，其它依次为心脏、脾、脑、睾丸、肺、肾、肌肉、血浆；各组织药物消除的速度依次为：脾、血浆、肌肉、肺、脑、肾、肝、睾丸及心脏，心脏消除最慢，ＭＲＴ为４．２７ｈ。我们认为：药物体内的脏器分布用统计矩法算出的ＡＵＣ、ＭＲＴ，再结合Ｃｍａｘ、Ｔｍａｘ等参数进行描述较为合理。
After iv injection of tetramethylpyrazine hydrochloride(TMPH)in rats,the concentration of TMPH in tissues was determined by ultraviolet spectrophotometry. The results showed that concentration of TMPH was highest in liver, followed by heart,spleen,brain,testis,lung,kidney, muscle, plasma. It was suggested that AUC and MRT calculated by moment analysis combined with Cmax and Tmax, were important parameters to evaluate drug distribution.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1994年第4期297-300,共4页
Chinese Pharmacological Bulletin
关键词
盐酸
川芎嗪
体内分布
统计矩
tetramethylpyrazine hydrochloride
distribution
statistical moment
AUC
MRT
