血管紧张素Ⅱ对缺氧自发性高血压大鼠和豚鼠主动脉血管收缩力的影响

Contraction effects of angiotensin Ⅱ on anoxia and non-anoxia SHR aorta and guinea pig aorta

观察血管紧张素Ⅱ（ＡｎｇⅡ）对缺氧及不缺氧自发性高血压大鼠（ＳＨＲ）和豚鼠主动脉的影响。发现缺氧后ＡｎｇⅡ明显加强豚鼠血管的收缩力，而ＡｎｇⅡ对ＳＨＲ血管收缩力影响不大，缺氧后ＡｎｇⅡ并没有加强其对ＳＨＲ血管的收缩作用。另外，用放免测定法测得缺氧后ＳＨＲ主动脉ＡｎｇⅡ含量显著减少，但豚鼠主动脉缺氧前后ＡｎｇⅡ含量却无明显变化，说明缺氧后ＳＨＲ血管对ＡｎｇⅡ的反应性与正常血管的不同。

This study was designed to investigate the effects of angiotensinⅡ on non-anoxia and anoxia SHR aorta and guinea pig aorta. We found that AngⅡ3￣300 nmol·L-1 significantly increased the contraction of guinea pig aorta in dose-dependent manner. Aorta contraction in guinea pig was more sensitive to AngⅡthan in non-anoxia SHR. After anoxia, the aorta contraction induced by AngⅡ was markedly increased in guinea pig but not in aorta of SHR. In addition, anoxia significant dicreased the content of AngⅡ of SHR aorta. However, there was no difference between non-anoxia and anoxia aorta of guinea pig in the concentration of AngⅡ.The results suggested that contraction responses of aorta to AngⅡ may be different between SHR and the guinea pig.