期刊文献+

脉冲电弧放电产生医用一氧化氮的放电条件研究 被引量:8

Study on Pulsed Arc Discharge Conditions on Production of Nitric Oxide for Medical Application
下载PDF
导出
摘要 NO作为救治急性呼吸衰竭综合征的新方法而受到关注。空气中的电弧放电可以产生NO。为满足NO医疗应用对NO2和NO2/(NOx)尽可能小的要求,实验采用负脉冲电弧放电,重点研究了电极间距、放电频率和电极极性等参数对NO和NO2浓度的影响。结果发现:NO2/(NOx)的比值在某电极间距范围内有一个最低值,NO和NO2浓度随电极间距和放电频率的提高而增加,电极极性对NO2/NOx比值的影响不明显。可以通过对放电条件的选择与组合,达到降低NO2浓度和NO2/(NOx)比值的目的。 As a new approach to treat acute respiratory distress syndrome, NO has recently received more attention, which may be generated by arc discharge in air. The concentration of NO2 and the ratio of NO2/(NOx) must be as little as possible for the medical application of NO. In this paper, NO is generated by negative pulsed discharge between needle and plate electrodes in dry air at the atmospheric pressure. Some important parameters affecting concentration of NO and NO2 have been investigated. These include the distance between electrodes, the pulsed discharge frequency and electrode polarity. The results show that the ratio of NO2/(NOx) is the lowest within one of the distances between electrodes and the concentration of NO and NO2 increases with raising of frequency and increasing of the distance between electrodes. Electrode polarity inconspicuously affects the ratio of NO2/NOx. The concentrations of NO2 and the ratio of NO2/(NOx) could be decreased by the choosing and combination of discharge conditions.
出处 《高压电器》 EI CAS CSCD 北大核心 2005年第3期176-178,共3页 High Voltage Apparatus
基金 国家自然科学基金项目(50347009) 国家科技攻关项目(2003A12)
关键词 电弧放电 电极 吸入性一氧化氮 急性呼吸衰竭综合征(ARDS) arc discharge electrode Inhaled nitric oxide acute respiratory distress syndrome(ARDS)
  • 相关文献

参考文献14

  • 1R Palmer, A C Fergie, S Moncada. Nitric Oxide Release Accounts for the Biological Activity of Endothelium Derived Relaxing Factor[J]. Nature, 1987(327): 524-556.
  • 2S L Davis, D P Funman, A T Costarino.Adult Respiratory Distress Syndrome in Children: Associated Disease, Clinical Course and Predictor of Death[J]. Pediatrics, 1993(123): 35-45.
  • 3Day RW, Guarin M, Lynch JM, et al. Inhaled Nitric Oxide in Children with Severe Lung Disease: Results of Acute and Prolonged Therapy with Two Concentrations[J].Crit.CareMed., 1996(24): 215.
  • 4叶志东,曹德生,刘鹏,陈鲁妮,高和,王辰.一氧化氮改善重症SARS患者氧合状态的即刻观察[J].中日友好医院学报,2003,17(6):330-331. 被引量:9
  • 5O Stenqvist, B Kjelltoft, S Lundin. Evaluation of A New System for Ventilatory Administration of Nitric Oxide[J]. Acta Anaesthesiol. Scadinav., 1993(37): 687-691.
  • 6周蓓华,张旭东,陈超,邵肖梅,黄国英,樊绍曾,孙波.吸入一氧化氮治疗新生儿低氧性呼吸衰竭[J].中华围产医学杂志,2001,4(4):222-225. 被引量:12
  • 7R H Clark, T J Kueser, M W Walker, et al. Low-dose Nitric Oxide Therapy for Persistent Pulmonary Hypertension of the New Born[J]. Nengl, JMed, 2000(342): 469-474.
  • 8The Neonatal Inhaled Nitric Oxide Study Group.Inhaled Nitric Oxide in Full-term and Nearly Full-term Infants with Hypoxic Respiratory Failure [J].Nengl Jmed,1997 (336):597-604.
  • 9S Cavadias. Analyse Et Modrlisation De La Synthese Des Oxides D'azote Dans Differents Reacteurs Plasmas [D].University Pierreet Marie Curie, Paris 6, 1987.
  • 10F Richard, J M Coemier, S Pellerin, et al. Nitrogen Oxide Production in Gliding arc Discharge [A]. In 11th Int. Conf.Gas Discharges and their Applications [C], Japan, Tokyo,1995(2) : 398-401.

二级参考文献21

  • 1[1]Drosten C,Gunther S,Preiser W,et al.Identification of a novel coronavirus in patients with severe acute respiratory syndrome[J].N Engl J Med,2003,348(20):1967-1976.
  • 2[3]Rossaint R, Falke KJ, Lopez F,et al.Inhaled nitric oxide for the adult respiratory distress syndrome[J].N Engl J Med,1993,328(6):399-405.
  • 3[4]Kinsella JP,Abman SH.Clinical approach to inhaled nitric oxide therapy in the new-born with hypoxemia[J].J Pediatr,2000,136(6):717-726.
  • 4[5]Blomqvist H,Wickerts CJ,Andreen M,et al.Enhanced pneumonia resolution by inhalation of nitric oxide? [J]Acta Anaesthesiol Scand,1993,37(1):110-114.
  • 5[6]Lindwall R,Frostell CG,Lǒnnqvist PA.Delivery characteristics of a combined nitric oxide nasal continuous positive airway pressure system[J].Paediatr Anaesth,2002,12(6):530-536.
  • 6[1]Waller DA, Gebitekin C, Saunders NR, et al. Noncardiogenic pulmonary edema complicating lung resection[J]. Ann Thorac Surg, 1993, 55(1): 140-143.
  • 7[2]Nakahara K, Nanjo S, Matsumura A, et al. Effect of pulmonary blood flow on lung water and pulmonary hemodynamics in the canine lung lobe[J]. Eur Surg Res, 1990, 22(3): 136-142.
  • 8[3]Wittnich C, Trudel J, Zidulka A, et al. Misleading "pulmonary wedge pressure" after pneumonectomy: its importance in postoperative fluid therapy[J]. Ann Thorac Surg, 1986, 42(2): 192-196.
  • 9[4]Mathru M, Blakeman B, Dries DJ, et al. Permeability pulmonary edema following lung resection[J]. Chest, 1990, 98(5): 1216-1218.
  • 10[5]Nicolaysen G, Waaller BA, Aarseth P. On the existance of stretchable pores in the exchange vessels of the isolated rabbit lung preparation[J]. Lymphology, 1979, 12(3): 201-207.

共引文献17

同被引文献83

引证文献8

二级引证文献20

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部