甲基莲心碱的血管作用与血管内皮及钙的关系

Effects of neferine on blood vessels and its relationship with endothelium and calcium

用机械摩擦法去血管内皮后，苯福林（Ｐｈｅ）预收缩的兔主动脉环不能被乙酰胆碱舒张，而甲基莲心碱（Ｎｅｆ）使之舒张的程度与内皮完整者相似。Ｎｅｆ温育１０ｍｉｎ可明显抑制ｐｈｅ的依内，外钙性缩血管作用，而对组胺的依内，外钙性缩血管作用抑制较弱。Ｎｅｆ尚对苯甲酸钠咖啡因在无钙液中收缩兔肠系膜动脉的作用有抑制，本文提示Ｎｅｆ的扩张血管作用无血管内皮依赖性；其对血管的作用机理可能主要与其抗Ｘ１肾上腺素受体及抗内钙释放有关。

After the endothelium being removedmechanically, the rabbit aortic rings(RA R) pre-contracted with phenylephrine(Phe) cant be relaxedby acetvlcholine,while can be relaxed by neferine(Nef)nearly to the same extent as in those with the intactendothelium Preincubation of Nef with RAR for 10min signifieantly inhibited the two phase vasoeonstri-ction of Phe but showed a weak effeet on that of histamine. Nef also showed an inhibitory effeet on the contraetive aetion of eaffeine in the rabbit mesenterieartery rings in the Ca2+ free medium. The results sug-gest that the vasodilative action of Nef is independentof endothelium.whereas is closely related to itsa1-adrenoceptor blocking and Ca2+-releasinginhibitory actions.