摘要
莲心碱(Lie)1-300umol·L1可浓度依赖性地降低离体豚鼠乳头状肌收缩力(Fe)和快反应劝作电位(AP)的零相上升幅度(APA)及最大除极速率(Vmax),延长动作电位时程(APD),且对Vmax的抑制作用有频率依赖性;同浓度下,其作用强于奎尼丁。对高K+诱发的慢AP,Lie也能剂量依赖性地降低APA,Vmax,Fe,其作用弱于维拉帕米。Lie还可对抗乙酰胆碱缩短APD的作用提示Lie对Na+,K+Ca2+的跨膜转运均有非特异性阻滞作用。
The effects of liensinine (Lie )on ae -tion potenthl(AP)and eontraetile foree(Fe)in iso-lated guinea pig myocardium were simultaneously ex- amined Lie1-300 umol·L could concentrationdependently reduce Fe,decline the amplittide(APA),Vmam.and prolong the duration(APD)of the action po-tential And it reduced Vmax、in a frequency depen-dent manner Lie could still concentrationdependently reduce the APA Vmax of the slow AP、and Fe At the same concentration the effeets of Lieon all the ahove parameters of the fast AP were strong-er than those of quinidine but effeets of Lie on those of the slow AP were mueh weaker than those of verapamil The effeet of acetylcholine 30 umol L on shortening the APD of the left auriele eould be antagonized by Lie 30umolL The antiarrhythmie effects of Lie can be explained by a nonspecific inhibi-tion of the current of Na+i K+ and ca2+
出处
《中国药理学与毒理学杂志》
CAS
CSCD
北大核心
1994年第1期46-48,共3页
Chinese Journal of Pharmacology and Toxicology
关键词
莲心碱
奎尼丁
动作电位
心肌收缩
Cardiovascular agents,liensinine
quinidine
verapamil
action potentials
myocardial contraetion