缺氧对血管紧张素收缩豚鼠主动脉的影响

Effects of anoxia on contraction of guinea pig aorta induced by angiotensin

缺氧对血管紧张素收缩豚鼠主动脉的影响董华进，汪巨峰，肖文彬（北京毒物药物研究所，１００８５０）血管紧张素（ａｎｇｉｏｔｅｎｓｉｎ，Ａｎｇ）是体内收缩血管作用较强的一类活性肽，其作用方式主要有两种：Ｌ，直接作用于血管上的Ａｎｇｌｌ受体而起作用；２．通过...

We studied the effects of angiotensinon the contraction of aorta in intact and anoxic guineapigs, and found that angiotensin Ⅰ(AngⅠ)andangiotensinⅡ(Ang Ⅱ)3300 nmol·L-1 significantly increased the contraction of the aorta andshowed a dose dependent manner After anoxia,thecontraction of the aorta induced by angiotensin wasmarkedly increased as compared with the un anoxicgroup.However, when the endothelium of vessels wasdamaged, the contraction of the aorta induced byAngⅠalmost disappeared,Although Ang Ⅱ broughtabout the adortic contrdction after the endothelium hadbeen damaged,the contractile potency was obviouslydecreased.Thecontractile duration of the aorta causedbyAng Ⅱ was prolongcd more in the damagedendothelium group than in the intact endotheliumgroup. There is no difference between intact andanoxic groups in the contraction induced by Ang Ⅱ.The resultS indicate that anoxia increases the contrac-tion of the guinea pig aorta induced by angiotensinwhichmavbear no re1ation to theactivity of theendogenous angiotensin system and yet depend on theendothelium of vessels.