人参总皂甙对大鼠脑缺血再灌注损伤的保护作用

Protective effects of total saponins of Panax ginseng onischemia-reperfusion injury in rat brains1

从病理生理，生化和超微结构方面研究表明，人参皂甙增加缺血再灌注脑血流量，减少钙积累，减轻脑水肿，延长双侧锁骨下和颈总动脉结扎后自主呼吸和脑电活动时间并促进再灌时的恢复，改善再灌注早期心脏功能，减轻超微结构损伤，降低缺血再灌注期间的死亡率。

Protective effects of ginsenosides(GS) on ischemia -reperfusion injury in rat brains werestudied pathophysiologically. biochemically andultrastructurally. The results demonstrate that GS in-crease cerebral blood flow. reduce Ca2+ accumulation.K+ loss and cerebral edema in cerebral cortex andhippocampus during reperfusion. improve the morphological appearance of the neurons in cerebral cortexand hippocampus at 60 inin of reperfusion. prolongthe duration of autononiic resniration and electroencephalogram activity after the occlusion of bilateralsubclavian and carotid artencs and proniote the recovery of the two physiological ftinctions. Correlation ana-lysis revealed a close relationship between the effects ofGS on Ca2+ accumulation and ultrastructural changes.suggesting that the protective effects of GS may resultfrom its Ca2+ reducing effect.