T2毒素对大鼠红细胞膜脂流动性及脂质过氧化的影响

Effect of T2 toxin on lipid fluidity and peroxidation of erythrocyte membrane of rats

Ｔ２毒素对大鼠红细胞膜脂流动性及脂质过氧化的影响彭双清，杨进生（北京毒物药物研究所，北京１００８５０）Ｔ２毒素是倍半萜类两歧性分子，极易与膜发生作用［１］．它能抑制ＤＮＡ，ＲＮＡ和蛋白质的合成，引起ＤＮＡ单链断裂及多核蛋白体分裂，以及与巯基酶相结合［...

In the present investigation,thechange of lipid fluidity andperoxidadon of raterythrocyte membrane treated with the trichothecenemvcotoxin T2 in vitro were examinel The results show-ed that T2 toxin had dose and time一detpendent effectson lipid fluidity of erythrocyte membrane。At T2 toxindoses of 1.0 and 10.0 mg·L-1 the membrane lipid flu-idity increased with the incubation time,at 100.0 mg·L-1,the highest dose tested,during the first 5 h,themembrane lipid fluidity increased,but then after 5 h,Feturned to the control level.In the tested doses of 5、0and 100.0mg·L-1,T2 toxin did not induced changeof concentration of membrane lipid peroxides.Thechange of erythrocyte membrane flexibility was one ofthe expression parameters of membrane injury inducedby T2 toxin。this change may be caused by T2 toxin in-teracting directly with the erythrocyte membrane。