摘要
清醒自由活动大鼠下丘脑后部内源性γ-氨基丁酸的释放郭莲军(武汉同济医科大学基础医学部药理教研室,武汉430030)γ-氨基丁酸(γ-aminobutyricacid,GABA)作为一种抑制性神经递质广泛分布于中枢神经系统,下丘脑后部含有大量的GABA...
Push-pull superfusion was used to in-vestigate the release
of cndogenous γ-aminobutyricacid(GABA)from the posterior hypothalamus of thefreely moving
conscious rat at basal conditions and inresponse to centrally applied drugs.After an
initial,exponential decline,the release rate of GABAremained fairly constant for many
hours.Fluctuationsinthe release rate of GABA point to the existence of anultradian rhythm with
an approximate frequency of 1cycle per 70 min.Hypothalamic superfusion with
apotassium-rich(50,90 mmol·L-1)artificialcerebrospinal fluid led to a
concentration-dependentincrease in the GABA release.Hypothalamicsuperfusion with the
tetrodotoxin(1μmol·L-1)led toa long-lasting decrease in the GABA release.
出处
《中国药理学与毒理学杂志》
CAS
CSCD
北大核心
1994年第3期229-230,共2页
Chinese Journal of Pharmacology and Toxicology
关键词
大鼠
下丘脑
氨基丁酸
γ
-aminobutyric acid
hypo-thalamus,posterior
tetrodotoxin,perfusion,regional