黏附分子CD44v3、CD44v6与非小细胞肺癌预后关系的研究

Relationship between the expressions of CD44v3,CD44v6 and prognosis of the patients with non-small cell lung cancer

目的研究CD44v3、CD44v6在非小细胞肺癌中的表达以及对生存率预测价值。方法本实验采用RTPCR和免疫组化等技术,对52例非小细胞肺癌患者手术标本进行CD44v3、CD44v6检测,并随访。结果低分化CD44v3、CD44v6的阳性表达率显著高于高分化和中分化(P<0.05),有淋巴结转移的肺癌患者CD44v3、CD44v6阳性表达率显著高于无淋巴结转移(P<0.05)。TMN分期中Ⅲ期显著高于1期和Ⅱ期(P<0.05)。多元Logistic回归分析显示,CD44v3、CD44v6阳性表达率和pTNM分期对生存率有显著影响(P<0.05)。结论检测CD44v3、CD44v6有助于预测肺癌患者术后生存。

Objective To study the expressions of CD44v3 and CD44v6 in non small cell lung cancer (NSCLC) and their prognositic value.Methods CD44v3,CD44v6 expressions were detected by reverse transcription polymerase chain reaction(RT-PCR) and immunohistochemistry (SP method) in 52 NSCLC tissues and 12 normal pulmonary tissues.Results Higher expression of CD44v3, CD44v6 was demonstrated in poor differentiation as compared with in moderate differentiation and in well differentiation (P<0.05). The expression of CD44v3,CD44v6 was much higher in patients with lymph node metastasis than in those without lymph node metastasis (P<0.05). The expression rate of CD44v3, CD44v6 in stage Ⅲ was remarkably higher than that in stage Ⅰ and Ⅲ. Muti-variate Logistic Analysis showed the expression of CD44v3, CD44v6 and p-TNM stage were significantly prognostic factor (P<0.05).Conclusion Detection of CD44v3, CD44v6 expressions may be helpful to predict the prognosis of lung cancer patients.