摘要
本文报道了鸭胆汁中新发现的胆甾酸３α，７α，２３－三羟基－５β－胆甾烷－２４－酸的分子构型转变的研究，通过选择性酰化分子中的３α和２３位羟基，再将７α羟基氧化成羰基，然后立体选择性地还原羰基为７β羟基，使原分子转变成３α，７β，２３－三羟基－５β－胆甾烷－２４－酸。所得的胆甾酸目前尚未见文献报道，通过１ＨＮＭＲ的考察，确定了它的分子结构。
This paper reported the molecular structural modification of 3α,7α,23-trihydroxylcholan-24-oic acid discovered in ducks'bile recently,into 3α,7β,23-trihydroxylcholan-24-oic acid by selectively acetylating its 3α-hydroxyl,oxidizing its 7α-hydroxyl into carbonyl,and then stereoselectively reducing the carbonyl.1he molecular structure of the synthetic acid,which had been an unknown compound,was elucidated with its 1HNMR.
出处
《中国药物化学杂志》
CAS
CSCD
1994年第2期97-100,共4页
Chinese Journal of Medicinal Chemistry
关键词
三羟基胆甾烷酸
分子构型
胆甾酸
合成
α,7α,23-trihydroxylcholan-24-oic acid
3α,7β,23-trihydroxylcholan-24-oic acid
Selective acetylation
Stereoselective reduction
