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KiSS-1蛋白metastin及基质金属蛋白酶-9在子宫内膜癌组织中的表达及意义 被引量：2

The expression and significance of KiSS-1 protein metastin and MMP-9 in endometrial carcinoma tissues
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摘要 目的检测KiSS-1及基质金属蛋白酶(MMP-9)在子宫内膜癌组织中的表达,探讨其临床意义及两者相关性。方法采用链霉菌抗生物素蛋白-过氧化酶连接(SP)法检测50例子宫内膜癌,13例子宫内膜上皮性瘤样病变(EIN)及18例正常子宫内膜组织中KiSS-1及MMP-9的表达情况和其与各种临床病理参数的关系,同时分析两者表达的相关性。结果KiSS-1蛋白metastin在子宫内膜癌组中的表达率(48.0%)明显低于EIN组(92.3%)及正常内膜组(83.3%),并且其在子宫内膜癌组中的表达率与临床分期、组织学分级、肌层浸润深度及淋巴结转移密切相关(P均<0.05)。MMP-9在子宫内膜癌组(58%)和EIN组(76.9%)中的表达明显高于正常内膜组(27.8%),其在子宫内膜癌组中的表达率也与临床分期、肌层浸润深度密切相关(P均<0.05)。KiSS-1蛋白metastin与MMP-9在子宫内膜癌中的表达存在明显负相关(P<0.05)。结论KiSS-1蛋白metastin的表达缺失和MMP-9的表达可能与子宫内膜癌的浸润、转移有关。
作者 姜涛 林蓓 马颖 张淑兰
机构地区 中国医科大学第二临床学院妇产科 中国医科大学第二临床学院病理科
出处 《广东医学》 CAS CSCD 北大核心 2005年第6期802-804,共3页 Guangdong Medical Journal
关键词 基质金属蛋白酶-9 KISS-1 癌组织 KISS-1 表达及 子宫内膜癌 MMP-9 肌层浸润深度 抗生物素蛋白 临床病理参数 子宫内膜组织 临床分期 组织学分级 淋巴结转移 表达率 临床意义 过氧化酶 表达情况 瘤样病变 相关性 链霉菌
分类号 R735.2 [医药卫生—肿瘤] R714.246 [医药卫生—妇产科学]
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参考文献6

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二级参考文献10

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同被引文献14

  • 1王春晖,乔宠,麻树人,周文平,戴显伟.KiSS-1基因及其蛋白在人胰腺癌组织中表达及其与侵袭和转移的关系(英文)[J].中国现代医学杂志,2005,15(11):1620-1623. 被引量：3
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引证文献2

二级引证文献1

广东医学
2005年 第6期

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