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DNA甲基化与妇科肿瘤

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摘要 DNA甲基化是哺乳动物表遗传机制,也是哺乳动物DNA惟一的自然化学修饰方式。但异常甲基化则为肿瘤发生的重要因素,在人类多种妇科肿瘤中都可以发现不同程度的DNA异常甲基化现象。本文介绍了哺乳动物DNA甲基化的特点及其抑制转录、表达的机制,DNA异常甲基化与妇科肿瘤发生、发展的关系,甲基化的检测方法及展望等。
出处 《徐州医学院学报》 CAS 2005年第3期274-277,共4页 Acta Academiae Medicinae Xuzhou
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