哌拉西林在胆道手术患者药代动力学的研究

Pharmacokinetics of piperacillin in patients Undergoing biliary tractSurgery

本文研究了哌拉西林（ｐｉｐｅｒａｃｉｌｌｉｎ，ＰＩＰ）在８例施各类胆道手术附Ｔ型管引流患者的药代动力学，采用ＡＶＡＮＴＡＧＥ全能自动化微生物分析仪测定血清及胆汁哌拉西林浓度。结果表明，静滴哌拉西林３ｇ或２ｇ后即刻血药浓度分别可达到３２２．７±２８．４和２０４．５±１６．２μｇ／ｍｌ，８ｈ后仍保持７．４±３．０和１．８±０．７μｇ／ｍｌ；Ｔ型管胆汁药物峰浓度可达到２０７．９±８３．６和１４４．７±６．６μｇ／ｍｌ，达峰时间约２ｈ左右。该药体内在观分布容积大于血容量，提示体内分布广泛，因静滴哌拉西林后血药及胆药浓度均较高，故适用于防治胆道感染。

We studied the pharmacokinetics of piperacillin(PIP)in patiens undergoing biliarytarct surgery with T tube. The concentrations of PIP in the blood and bile were measured by us-ing Avantage Microbiology System (Abbott).The concentrations of PIP in the blood after intra-venous infusion in single dose of 3g or 2g went up to 322. 7±28. 4 and 204. 5±16.2μg/ml.After 8hours they were 7.4±3.0 and 1. 8±0.7μg/ml. The peak concentrations in the bile in T tube wereup to 207.9±83, 6 and 144.7±6.6μg/ml.The time for peak concentration in the bile was about 2hours. The volume of appearance distribution was more than the volume of blood,suggesting thatthe PIP was widelv distributed in the body. The concentrations of PIP in the blood and bile afterinfusion were high,so PIP may be used to prevent and treat infections of the biliary tract.