普萘洛尔对人体心脏变时性反应及安替比林代谢的影响

Influence of propranolol on cardiac chronotropic response and an-tipyrine metabolism in man

１０例正常受试者口服普蔡洛尔１０ｍｇ，ｔｉｄ，持续７ｄ后，异丙基肾上腺素的变时性剂量（ｃｈｒｏｎｏｔｒｏｐｉｃｄｏｓｅ＿（２５），ＣＤ＿（２５）从１．４±０．５μｇ增加到８．８±４．９μｇ，平均β－受体阻滞指数为７．１；卧位择时心率明显减慢，安替比林代谢受到抑制。说明短期小量使用普蔡洛尔，能产生β－受体阻滞作用和抑制安替比林代谢。

After taking propranolol 10mg,thrice daily,for 7 days,the chronotropic dose_(25)(CD_(25))of isoproterenol was increased from 1.4±0.5μg to 8.8±4.9μg in 10 volunteers;the meanβ-receptor blocking index was 7.1.The chrono-heart rate in supine position was obviously de-creased and antipyrine metabolism inhibited.The results indicated that the use of propranolol inshort-term and small dose could produce the β-receptor blocking effect and the inhibition of antipyrine metabolism.