双氯灭痛控释片的释药机理及影响释药的因素

Mechanisms of Diclofenac sodium release from controlled-releasetablets and factors affecting release rate

双氯灭痛（ＤＣ－Ｎａ）亲水凝胶骨架片及不溶性骨架片体外均能控制ＤＣ－Ｎａ释药１２ｈ，亲水凝胶骨架片释药机理符合一级动力学，ｌｇ（１－Ｆ）＝０．１８６５－０．１１７７ｔ，相关系数ｒ＝０．９９２８，不溶性骨架片释药机理符合Ｈｉｇｕｃｈｉ方程，相关系数ｒ＝０．９９１６，释药递质的ｐＨ对ＤＣ－Ｎａ释药速度没有明显影响，转篮转达为５０或１００ｒ／ｍｉｎ释药速度没有明显变化。

Diclofenac sodium can be released continuously from hydrophilic and insolublematrices for more than 12 hours in vitro. The mechanism of hydrophilic matrix is first-orderkinetics,lg(1-F)=0.1865-0.1177t,r=-0.9928 and that of insoluble matrix is the square rootkinetics,F=0. 3226t￣(1/2)-0.1503,r=0.9916.Medium pH affects significantly the release rate ofDiclofenal sodium, There is no notable effect in stirring rate between 50 and 100 r/min for therelease rate of Diclofenal sodium.