65例系统性红斑狼疮患者抗中性粒细胞胞浆抗体的检测分析

Clinical Study of Antineutrophil Cytoplasmic Antibodies in 65 Patients with Systemic Lupus Erythematosus

目的探讨抗中性粒细胞胞浆抗体(ANCA)与系统性红斑狼疮(SLE)的关系及临床意义。方法回顾性分析65例SLE患者的ANCA检测结果;ANCA与SLE主要临床表现、实验室检查结果的关系;SLE患者病情活动组与非活动组ANCA阳性率的比较。结果IIF法检测ANCA在SLE中的阳性率是61.5%,ANCA阳性组中有血管炎皮损(67.5%)及浆膜炎(55.0%)者明显高于阴性组(P<0.05);同时ANCA阳性组与阴性组比较,在24h尿蛋白大于0.5g/L,血红蛋白低于90g/L,抗ds-DNA抗体阳性,低补体血症方面差别有统计学意义(P<0.05)。结论提示ANCA可能是判断SLE病情复发与缓解的一个有用指标,推测ANCA与活动性狼疮肾炎有关。

Objective To study the relationship between antineutrophil cytoplasmic antibodies(ANCA) and systemic lupus erythematosus(SLE). Methods Clinical data of 65 patients with SLE, who were examined ANCA in the sera by indirect immunoflourescence technique(IIF),were studied retrospectively. Results The positive rate of ANCA in SLE patients was 61.5 % by IIF. The patients with cutaneous vasculitic manifestation in the group of positive ANCA were more than ones in the group of negtive ANCA, the difference between the two groups was very significant(P<0.05). So were the patients with serositis. There also was significant difference in exceeding 0.5 g/L of urinary protein in 24 hours, patients with positive anti-ds-DNA, lowing 90 g/L of Hb, patients with hypocomplementemia (P<0.05). Conclusions ANCA in some patients with SLE were positive. ANCA might be correlated with lupus activities and renal's invasions.