啤酒酵母中海藻糖合成酶和海藻糖-6-磷酸合成酶的功能及结构分析

Analysis of Structure & Functions of Trehalose Synthetase & Trehalose-6-phosphasynthetase in Beer Yeast

啤酒酵母的海藻糖合成酶复合物由4个亚基(TPS1,TPS2,TPS3和TSL1)组成,这4个亚基具有协同作用。其中海藻糖-6-磷酸合成酶是海藻糖合成酶的功能中心;TPS1除了具有合成海藻糖的功能之外,还具有调节糖代谢和促进酵母孢子形成的功能;tps1大量表达时,有助于细胞增加对高温、高渗和酒精等的耐受性。

Trehalose synthetase in beer yeast was composed of four subunits including TPS1, TPS2, TPS3 and TSL4 with synergetic effects. Trehalose-6-phosphasynthetase was the function center of trehalose synthetase. Except the function of trehalose synthesis, TPS1 also had the functions of adjusting sugar metabolism and advancing the formation of yeast spore. The overexpression of tps1 was helpful for improving heat-resistance, alcohol-resistance and permeation-resistance of cells. (Tran. by YUE Yang)