荫风轮总苷止血作用研究

Research on hemostatic effect of total saponins of Yinfenglun

目的:研究荫风轮总苷治疗出血证的药理作用。方法:观察断尾小鼠出血时间及出血量,不同动物凝血时间以及凝血功能试验。结果:荫风轮总苷不同剂量可明显缩短小鼠断尾出血时间,减少出血量,并能缩短小鼠、大鼠、犬凝血时间;可明显缩短家兔血浆复钙时间、凝血酶原时间和白陶土部分凝血活酶时间,但对大鼠优球蛋白溶解时间无明显影响,表明荫风轮总苷既能影响内源性凝血系统,又能影响外源性凝血系统。结论:荫风轮总苷具有显著的止血作用。

Objective: To research the hemostatic effect of total saponins of Yinfenglun. Method: Bleeding time and volume were dete-minded in mice after tails being cut. Qotting times were researched on mice, rats and dogs. Hemostatic mechanism total saponins of Yinfenglun were studied on plasma recalcified time, FT, KFTT and ELT. Result: TSY at different doses could markedly shorten bleeding time, reduce bleeding volume in mice. TSY also could shorten clotting time of mouse, rat and dog. TSY could influence both intrinsic coagulatian system and extrinsic coagulatian system, and had no effect of antifibrinolysis. Conclusion: There were obvious hemostatic effect of total saponins of Yinfenglun.