2－羧乙基锗倍半氧化物药代动力学研究

Pharmacokinetic Studies of 2-Carboxyetbyl germanium Sesquioxide

在分别单剂量静脉应用２４ｍｇ／ｋｇ，１２０ｍｇ／ｋｇ，６００ｍｇ／ｋｇ和单剂量口服１２０ｍｇ／ｋｇ后，用原子吸收光谱，ＩＢＭＰＣ微机和３Ｐ８７程序研究２－羧乙基锗倍半氧化物（Ｇｅ－１３２）于家兔体内的药动学参数。结果表明，各静注剂量组的时－浓曲线均属一级动力学，二房室模型，消除相半衰期接近，约为７５ｍｉｎ。中高剂量组的表观分布容积分别是０．１９９５Ｌ／ｋｇ和０．２０４１Ｌ／ｋｇ，二者比较接近。而低剂量组的表观分布容积是２．３１８Ｌ／ｋｇ。随着用药剂量的增加，药物的消除动力学没有变成零级动力学。口服Ｇｅ－１３２１２０ｍｇ／ｋｇ后，峰值时间为２．９５ｈ，生物利用度为１８％。

he pharmacokinetic parameters of 2-carboxyethylgermanium sesquioxide(Ge-132) were investi-gated by 180-80 AAS and computer 3P87 programs after a single intravenous administration of 24 , 120,600 mg /kg of Ge-132 respectively and a single oral administration of 120mg/kg of Ge-132 in rabbits.The results showed that the time-concentration curves of Ge-132 in different dosage-groups all belonedto the first order kinetics,the two-compartment models,The half-life time of elimination phase wasguite near they were 75min approximately. The apparent volumes of distribution were 0.1995 and 0.2041 L/kg at doses of both 120 and 600 mg/kg respectively,and 2.318 L/kg at a dose of 24 mg/kg in-traveneously. The elimination kinetics of the drug didn′ t change into zero order kinetics as the dosage ofthe drug was increased.The peak time was 2. 95 h after a oral administration of 120 mg/kg of Ge-132.The bioavailability was 18%.