加热灭活乙肝血源疫苗在健康成人中一年免疫效果评价

Efficacy of Heat-inactivated HB Vaccine in Healthy students

筛选２０４名健康成人为免疫对象，分为Ａ、Ｂ两组，分别接种加热灭活和福尔马林灭活的乙肝血源疫苗。每组选用两种剂量（７μｇ，１４μｇ），并于首次免疫后Ｔ１、Ｔ３、Ｔ７、Ｔ１２采血，用Ａｂｂｏｔｔ试剂药上测其抗－ＨＢｓ水平。对加热灭活乙肝血源疫苗进行一年免疫效果对比评价。结果表明：Ｔ３抗－ＨＢｓ阳性率和乙抗－ＨＢｓ滴度＞１００ｍＩＵ／ｍｌ者的比例在两种疫苗组之间无显著性差异。Ｔ７接种加热灭活乙肝疫苗１４μｇ者的抗－ＨＢｓ阳性率（９６．６％）和抗－ＨＢｓ滴度＞１００ｍＩＵ／ｍｌ者的比例（９３．２％）显著高于接种福尔马林灭活疫苗者（８３．３％和７６．２％）。但Ｔ１２两者之间差异消失。随访期间抗－ＨＢｓＧＭＴ两疫苗组之间始终无显著差异。初步证实加热灭活乙肝血源疫苗具有良好的免疫原性。

ndividuals of, 240 with negative for out HBV markers were divided into 2 groups , and vaccinatedwith heat-inactivated and three steps inactivated plasrna-derived HB vaccines respectively。Participants in each group received 2 doses of vaccine ( 7μg, 14μg );Blood samples were taken out atmonths T1,T3 ,T7,T12 after the first vaccination,Anti-HB.was tested by radioimmunoassay withAbbott Laboratories kit to study the efficacy of heat inactivated HB vaccine first made in China。Therisult showed that the difference of T3 anti-HB,seroconversion rates and percentages of T3 vaccineswith anti-HB。 titre> 100mIU/ml in two groups was not significant.However,for T7 after the firstvaccination,the value in group with heat inactivated was significantly higher than that in group withthree steps inactivated HB vaccine。For T12 after the first vaccination, the differences disappeared.Nodifference in anti-HB,GMT was seen in two groups during the following up period。The resultssuggested that heat inactivated HB vaccine is of the efficacy as three steps inactivated HB vaccine。