多普勒超声心动图评价降压治疗对高血压病患者心功能的改善作用

Assessment of Left Veutricular Function with Doppler Echocardiography in Hypertensive patients before and after Antihypertensive Treatment

采用脉冲多普勒超声心动图（ＰＤＥ）测定３０例高血压病患者（Ⅰ期１３例，Ⅱ期１７例）的左心功能，并与２０例正常人比较。结果显示：高血压病早期，舒张功能已受损害。随着病情发展，舒张功能损害加重，并出现左室收缩功能受损倾向。口服依那普利治疗４周后，血压明显下降，同时左室舒张功能明显改善。

o evaluate left ventricular systolic and diastolic functions,30 patients with hypertension (blood pressure 22.60±1.90/14.84±1.14kPa)and 20 normal subjects of similar age(55.9±8.1 and 54.5±8.4 years,blood pressure 16.08±2.01/10.31±1.24kPa)underwent examination of the LV function before and after treatment with Enalapril by M-mode echocardiography,2-Dimensional echocardio-graphy and Pulsed Doppler,The results showed the peak velocity of early filling(E velocity)signifi-cantly decreased(P<0.01)the ratio of the peak veolcity of late filling(A velocity)and E velocity (A/E)increased(P<0.01 )and IDTwas prolonged (P<0.05 ),While LVEF,LVFS and AOV were still normal,With the progression of the disease,above exagerated indice and A velocity increased signifi-cantly (P<0.01).AOV had the tendency of decline.After they have received Enalapril for 4 WK,blood pressure decreased markedly,most indice of diastolic function were improved.While LVEF、LVFS and AOV nearly unchanged(P>0.05 ).It demonstrates that diastolic dysfunction often precedes systolic dys function in hypertension;Enalapril can effectively decrease blood pressure and improve left ventric-ular diastolic function.