摘要
采用脉冲多普勒超声心动图(PDE)测定30例高血压病患者(Ⅰ期13例,Ⅱ期17例)的左心功能,并与20例正常人比较。结果显示:高血压病早期,舒张功能已受损害。随着病情发展,舒张功能损害加重,并出现左室收缩功能受损倾向。口服依那普利治疗4周后,血压明显下降,同时左室舒张功能明显改善。
o evaluate left
ventricular systolic and diastolic functions,30 patients with hypertension (blood pressure
22.60±1.90/14.84±1.14kPa)and 20 normal subjects of similar age(55.9±8.1 and 54.5±8.4
years,blood pressure 16.08±2.01/10.31±1.24kPa)underwent examination of the LV function
before and after treatment with Enalapril by M-mode echocardiography,2-Dimensional
echocardio-graphy and Pulsed Doppler,The results showed the peak velocity of early filling(E
velocity)signifi-cantly decreased(P<0.01)the ratio of the peak veolcity of late filling(A
velocity)and E velocity (A/E)increased(P<0.01 )and IDTwas prolonged (P<0.05 ),While
LVEF,LVFS and AOV were still normal,With the progression of the disease,above exagerated
indice and A velocity increased signifi-cantly (P<0.01).AOV had the tendency of decline.After
they have received Enalapril for 4 WK,blood pressure decreased markedly,most indice of
diastolic function were improved.While LVEF、LVFS and AOV nearly unchanged(P>0.05 ).It
demonstrates that diastolic dysfunction often precedes systolic dys function in
hypertension;Enalapril can effectively decrease blood pressure and improve left ventric-ular
diastolic function.
出处
《中国医科大学学报》
CAS
CSCD
1994年第5期458-460,共3页
Journal of China Medical University