线粒体中的丝氨酸蛋白酶在肿瘤发生中的作用
Roles of serine proteases residing in the mitochondria in carcinogenesis
摘要
线粒体在参与调节内环境稳定和细胞凋亡上发挥重要作用,其基因异常表达与肿瘤发生密切相关。线粒体中的丝氨酸蛋白酶LON/PIM1执行管家功能和调节功能,其异常表达可影响氧化磷酸化及内环境稳定,并且使细胞凋亡发生异常,从而促发肿瘤;另一个丝氨酸蛋白酶Omi/HtrA2主要在调节细胞凋亡发生中起重要作用,Omi/HtrA2的异常表达也可导致肿瘤发生。
出处
《国外医学(肿瘤学分册)》
2005年第6期423-426,共4页
Foreign Medical Sciences (Cancer Section)
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