新生儿柯萨奇病毒感染死亡病例临床及病理分析

The Clinical And Patholgic Analysis o Died Cases of Neonaie with Coxsackie Virus B3 and B5 Ineection

１９９３年９月下旬～１０月末，沈阳某妇婴医院新生儿柯萨奇（Ｃｏｘ－Ｂ３Ｂ５）病毒感染暴发流行，１０月中上旬为流行高峰，临床表现以心肌损害为主，死亡原因为多脏器功能衰竭，尸检证实均为急性非化脓性心肌炎改变，部分有肺泡内出血，肝细胞大片坏死及肾小管远端钙化。病原学检测５例，３例ＩｇＭ抗体阳性，其中Ｃｏｘ－Ｂ５１例，Ｂ３与Ｂ５同时感染２例，２例于心包液，心血及心肌中分离出肠道病毒。

fulminant epidemic of coxsackie virus B3 and B5 infection in enonates occured in Maternity and in-fant hospital in Shenyang,fron late september to october in 1993.38 cases were treated in our neonatalintensive cure unite,8 cases died, the cause of death was function failure,of multiple organs 5 cases au-topsy confirmed that all patients had acute myocarditis,4 cases had lung hemorrhage,3 cases showedliver cell necrosis,2 cases presented calcification of the distance of renal tube,3 cases showed IgM anti- body positive(1 cases was coxsackie vetus B5 infection,2 cases were B3 and B5),enterovirus was isolat-ed in heart blood, myocardium and fluid of pericardium in 2 cases.