骨桥蛋白与肿瘤研究进展
Osteopontin and carcinomas
摘要
近年研究表明骨桥蛋白(OPN)与肿瘤关系密切,参与肿瘤发展的多个环节。现简要综述骨桥蛋白与Ras癌基因的关系及其在促肿瘤恶化、抑制凋亡、逃避肿瘤免疫、促肿瘤浸润转移及血管生成等方面的作用。
出处
《国外医学（肿瘤学分册）》
2005年第6期444-447,共4页
Foreign Medical Sciences (Cancer Section)
参考文献28
-
1Teramoto H, Castellone MD, Malek RL, et al. Autocrine activation of an osteopontin-CD44-Rac pathway enhances invasion and transformation by H-RasV12.Oncogene,2005,24 (3) :489-501.
-
2Wu Y, Denhardt DT, Rittling SR. Osteopontin is required for full expression of the transformed phenotype by the ras oncogene. Br J Cancer,2000,83 ( 2 ) : 156-163.
-
3Khan SA, Lopez Chua CA,Zhang J, et al. Soluble osteopontin inhibits apoptosis of adherent endothelial cells deprived of growth factors. J Cell Biochem,2002,85 (4) :728-736.
-
4Noti JD. Adherence to osteopontin via alphavbeta3 suppresses phorbol ester-mediated apoptosls in MCF-7 breast cancer cells that overexpress protein kinase C-alpha. Int J Oncol,2000,17(6) :1237-1243.
-
5Geissinger E, Weisser C, Fischer P, et al. Autocrine stimulation by osteopontin contributes to antiapoptotic signaling of melanocytes in dermal collagen. Cancer Res,2002,62(16) :4820-4828.
-
6Fedarko NS,Fohr B ,Robey PG,et al. Factor H binding to bone sialoprotein and osteopontin enables tumor cell evasion of complement-mediated attack. J Biol Chem,2000,275 (22) : 16666-16672.
-
7Jain A, Karadag A, Fohr B, et al. Three SIBLINGs ( small integrinbinding ligand,N-linked glycoproteins) enhances factor H's cofactor activity enabling MCP-like cellular evasion of completment-mediated attack. J Biol Chem,2002;277 (16) : 13700-13708.
-
8Zohar R, Suzuki N, Suzuki K, et al. Intracellular osteopontin is an intergral component of the CD44-ERM complex involves in cell migration. J Cell Physiol,2000,184 ( 1 ) : 118-130.
-
9Irby RB, McCarthy SM, Yeatman TJ. Osteopontin regulates multiple functions contributing to human colon cancer development and progression. Clin Exp Metastasis,2004,21 (6) :515-523.
-
10Adwan H, Bauerle TJ, Berger MR. Downregulation of osteopontin and bone sialoprotein H is related to reduced colony formation and metastasis formation of MDA-MB-231 human breast cancer cells. Cancer Gene Ther,2004,11 (2) :109-120.
-
1俞文华,张国新.骨桥蛋白:一种新的肿瘤标志物[J].国际检验医学杂志,2006,27(12):1109-1111. 被引量：8
-
2李姝,马湘一,卢运萍,王世宣,马丁.骨桥蛋白、CD44v6在宫颈癌组织中的表达及其临床意义[J].中国医师杂志,2007,9(11):1445-1447. 被引量：3
-
3陈淑勤,高凌云,汪晓军,陈崧.OPN和uPA mRNA在肝细胞癌组织中的表达及临床意义[J].中国误诊学杂志,2008,8(36):8823-8825. 被引量：1
-
4付汐,杨竹林,李代强,苗雄鹰.胰腺癌组织中Kai1和骨桥蛋白表达及其临床病理意义[J].中国医师杂志,2006,8(12):1690-1691. 被引量：2
-
5王凤玲,庞新英,于彩洁.非小细胞肺癌中骨桥蛋白和细胞间黏附分子-1的表达及临床意义[J].中国误诊学杂志,2009,9(10):2303-2304.
-
6张红梅,张敬川.Osteopontin与乳腺癌侵袭转移[J].中华肿瘤防治杂志,2007,14(23):1827-1829.
-
7王洪海,蒋文涛,邓永林,朱志军.联合检测术前、术后血浆骨桥蛋白表达预测肝细胞癌切除术预后[J].天津医药,2009,37(3):177-179.
-
8乌新林,冯立民,王占民,吴小鹏.p53、bcl-2、c-erbB-2在胃癌及癌前病变中表达的意义[J].中国现代普通外科进展,2005,8(1):37-39. 被引量：16
-
9邓春燕,谭晓琴,李涛,黄建鸣.上皮-间质转化及其干性作用与肿瘤[J].国际肿瘤学杂志,2013,40(12):899-902. 被引量：2
-
10孟淑燕,郁佳,方启宇,吕梅君.非小细胞肺癌对EGFR-TKIs产生获得性耐药后发生小细胞肺癌转化的研究进展[J].肿瘤,2016,36(9):1070-1074.
