期刊文献+

蛋白质组学在卵巢癌研究中的应用

Protemics applications in ovarian cancer
下载PDF
导出
摘要 蛋白质组学具有高通量、全面和动态地研究蛋白质变化的特点,尤其在筛选早期诊断卵巢癌的肿瘤标记物方面更具有优越性,并且利用不同肿瘤标记物的数目重新对卵巢肿瘤进行更为有利于治疗的分型。还可根据变化的蛋白质,分析卵巢癌的信号转导、凋亡、浸润和化疗耐药性机制。现将近年来蛋白质组学在卵巢癌研究中的应用综述如下。
作者 赵宏伟 王波
出处 《国外医学(肿瘤学分册)》 2005年第6期464-467,共4页 Foreign Medical Sciences (Cancer Section)
  • 相关文献

参考文献15

  • 1Greenlee RT, Hill Harmon MB, Murray T, et al. Cancer statistics,2001. Ca Cancer J Clin,2001,51 ( 1 ) :15-36.
  • 2Greenlee RT, Murray T, Bolden S, et al. Cancer statistics,2000. Ca Cancer J Clin,2000,50( 1 ) :7-33.
  • 3Gevaert K, Vandekerckhove J. Protein identification methods in proteomics. Electrophoresis ,2000,21 (6) : 1145-1154.
  • 4Rai AJ, Zhang Z, Rosenzweig J, et al. Prcteomic approaches to tumor marker discovery. Arch Pathol Lab Med,2002,126 (12) : 1518-1526.
  • 5Ye B, Cramer DW, Skates SJ, et al. Haptoglobin-alpha subunit as potential serum biomarker in ovarian cancer: identification and characterization using proteomic profiling and mass spectrometry. Clin Cancer Res, 2003,9(8) :2904-2911.
  • 6Petricoin EF, Ardekani AM, Hitt BA, et al. Use of proteomic patterns in serum to identify ovarin cancer. Lancet,2002,359:572-577.
  • 7Wulfkuhle JD, Aquino JA, Calvert VS, et al. Signal pathway profiling of ovarian cancer from human tissue specimens using reversephase protein microarrays. Proteomics,2003, ( 11 ) :2085-2090.
  • 8Young TW, Mei FC, Yang G, et al. Activation of antioxidant pathways in ras-mediated oncogenic transformation of human surface ovarian epithelial cells revealed by functional proteomics and mass spectrometry. Cancer Res, 2004,64( 13 ) :4577-4584.
  • 9Hu W, Wu W, Verschraegen CF, et al. Proteomic identification of heat shock protein 70 as a candidate target for enhancing apoptosis induced by farnesyl transferase inhibitor. Proteomics, 2003,3 ( 10 ) :1904-1911.
  • 10Jones MB, Krutzsch H, Shu H, et al. Proteomic analysis and identification of new biomarkers and therapeutic targets for invasive ovarian cancer. Proteomics, 2002,2(1) :76-84.

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部